Scientific publications

• Kapczynski DR, Segovia K, Chrzastek K, Conceicao C, Suarez DL, Vervelde L, Digard P. Novel technology to develop non-transmissible live influenza virus vaccines through alterations in M2/M42 ion channel expression. bioRxiv 2023.04.11.536210; doi: https://doi.org/10.1101/2023.04.11.536210
• Sid H, von Heyl T, Schleibinger S, Klinger R, Vikkula H, Guabiraba R, Guillory V, Alhussien M, Böhm B, Schade B, Elleder D, Sives S, Vervelde L, Trapp S, Schusser B. (2024) Reinstatement of RIG-I in chickens via genetic modification reveals new insights into the dynamic evolution of avian immune sensors. bioRxiv 2023.11.01.564710; doi: https://doi.org/10.1101/2023.11.01.564710
• Glendinning L, Wu Z, Vervelde L, Watson M, Balic A. (2024) Infectious bronchitis virus vaccination, but not the presence of XCR1, is correlated with large differences in chicken caecal microbiota. Microbial Genomics, 10 (9), doi.org/10.1099/mgen.0.001289
• Aleksandrowicz A, Brødsgaard Kjærup R, Grzymajło K, Garcia Martinez F, Muñoz J, Borowska D, Sives S, Vervelde L, Sørensen Dalgaard T, Kingsley RA, Kolenda R. (2024) FdeC expression regulates motility and adhesion of the avian pathogenic Escherichia coli strain IMT5155. Veterinary Research, 55, 70. doi.org/10.1186/s13567-024-01327-5
• Härtle S, Sutton KM, Vervelde L*, Sørensen Dalgaard T*. (2024) Delineation of chicken immune markers in the era of omics and multicolour flow cytometry. Frontiers in Veterinary Science, 11:1385400. doi: 10.3389/fvets.2024.1385400
• Mitchell J, Sutton K, Elango JN, Borowska D, Perry F, Lahaye L, Santin E, Arsenault RJ, Vervelde L. (2024) Chicken intestinal organoids: a novel method to measure the mode of action of feed additives. Frontiers in Immunology, 15:1368545. doi.org/10.3389/fimmu.2024.1368545
• Morris KM, Sutton K, Girma M, Sánchez-Molano E, Solomon B, Esatu W, Dessie T, Vervelde L, Psifidi A, Hanotte O, Banos G. (2024) Phenotypic and genomic characterisation of performance of tropically adapted chickens raised in smallholder farm conditions in Ethiopia. Frontiers in Genetics, 15:1383609. doi: 10.3389/fgene.2024.1383609.
• Corona-Torres R, Vohra P, Chintoan-Uta C, Bremner A, Terra VS, Mauri M, Cuccui J, Vervelde L, Wren BW, Stevens MP; Glycoengineering of Veterinary Vaccines Consortium. (2024) Evaluation of a FlpA glycoconjugate vaccine with ten N-Heptasaccharide glycan moieties to reduce Campylobacter jejuni Colonisation in Chickens. Vaccines, 12(4):395. doi: 10.3390/vaccines12040395.
• Zeinali, S., Sutton, K., Zefreh, M. G., Mabbott, N., and Vervelde, L. (2024). Discrimination of distinct chicken M cell subsets based on CSF1R expression. Scientific Reports, 14(1), 8795.
• Sives S, Keep S, Bickerton E, Vervelde L. (2023) Revealing Novel-Strain-Specific and Shared Epitopes of Infectious Bronchitis Virus Spike Glycoprotein Using Chemical Linkage of Peptides onto Scaffolds Precision Epitope Mapping. Viruses, 15(11):2279. doi: 10.3390/v15112279.
• Zeinali S, Sutton K, Vervelde L. (2024) Distribution and spatiotemporal development of organised lymphoid tissues in the chicken intestinal tract. Developmental and Comparative Immunology, 151:105096 doi.org/10.1016/j.dci.2023.105096
• Sutton K, Nash T, Sives S, Borowska D, Mitchell J, Vohra P, Stevens MP, Vervelde L. (2023) Disentangling the innate immune responses of intestinal epithelial cells and lamina propria cells to Salmonella Typhimurium Infection in chickens. Frontiers in Microbiology, 14:1258796 doi.10.3389/fmicb.2023.1258796
• Hussein MA, Khattak F, Vervelde L, Athanasiadou S, Houdijk JGM. (2023) Sensitivity of broiler performance, organ weights and plasma constituents to amino acid supplementation and reused litter exposure using ideal protein formulated rations. Animal, 100985, doi.org/10.1016/j.animal.2023.100985
• Hussein MA, Khattak F, Vervelde L, Athanasiadou S, Houdijk JGM. (2023) Growth performance, caecal microbiome profile, short-chain fatty acids, and litter characteristics in response to placement on reused litter and combined threonine, arginine and glutamine supplementation to juvenile male broiler chickens. Animal Microbiome, 5(1):18. doi: 10.1186/s42523-023-00240-0
• Sharp CP, Thompson BH, Nash TJ, Diebold O, Rute RM, Thorley L, Lin Y-T, Sives S, Wise H, Clohisey-Hendry A, Grey F, Vervelde L, Simmonds P, Digard P, Gaunt ER. (2023) CpG dinucleotide enrichment in the influenza A virus genome as a live attenuated vaccine development strategy. PLoS Pathogens 19(5): e1011357.
• Morris KM, Mishra A, Raut AA, Gaunt ER, Borowska D, Kuo RI, Wang B, Vijayakumari P, Chingtham S, Dutta R, Baillie K, Digard P, Vervelde L, Burt DW, Smith J. (2023) The molecular basis of differential host responses to avian influenza viruses in avian species with differing susceptibility. Frontiers Cellular & Infection Microbiology, 13 doi.org/10.3389/fcimb.2023.1067993
• Bryson KJ, Sives S, Lee H-M, Borowska D, Smith J, Digard P, Vervelde L. Comparative Analysis of Different Inbred Chicken Lines Highlights How a Hereditary Inflammatory State Affects Susceptibility to Avian Influenza Virus. (2023) Viruses, 15(3):591. doi.org/10.3390/v15030591
• Nash TJ, Morris KM, Mabbott NA, Vervelde L. (2023) Temporal transcriptome profiling of floating apical out chicken enteroids suggest stability and reproducibility. Veterinary Research, 54, 12 doi.org/10.1186/s13567-023-01144-2
• Smith J, et al. Fourth Report on Chicken Genes and Chromosomes (2022) Cytogenetic and Genome Research, doi.org/10.1159/000529376
• Borowska D, Sives S, Vervelde L* and Kate M. Sutton KM*. (2022) Chicken CSF2 and IL-4-, and CSF2-dependent bone marrow cultures differentiate into macrophages over time. Frontiers in Immunology, 13:1064084. doi: 10.3389/fimmu.2022.1064084
• Mountford J, Gheyas A, Vervelde L, Smith J. (2022) Genetic variation in chicken interferon signalling pathway genes in research lines showing differential viral resistance. Animal Genetics, 53(5):640-656. doi: 10.1111/age.13233.Nash T and Vervelde L. (2022) Advances, challenges and future applications of avian intestinal in vitro models. Avian Pathology, 51(4):317-329. doi:10.1080/03079457.2022.2084363.
• Sutton KM, Orr B, Hope J, Jensen SR, Vervelde L. (2022) Establishment of bovine 3D enteroid-derived 2D monolayers. Veterinary Research, 53(1):15. doi: 10.1186/s13567-022-01033-0.
• Zamperin G, Bianco A, Smith J, Bortolami A, Vervelde L, Schivo A, Fortin A, Marciano S, Panzarin V, Mazzetto E, Milani A, Berhane Y, Digard P, Bonfante F, Monne I. (2021) Heterogeneity of Early Host Response to Infection with Four Low-Pathogenic H7 Viruses with a Different Evolutionary History in the Field. Viruses, 13(11):2323. doi: 10.3390/v13112323.
• Orr B, Sutton K, Christian S, Nash T, Niemann H, Hansen LL, McGrew MJ, Jensen SR, Vervelde L. (2021) Novel chicken two-dimensional intestinal model comprising all key epithelial cell types and a mesenchymal sub-layer. Veterinary Research, 52(1):142. doi: 10.1186/s13567-021-01010-z.
• Vohra P, Chintoan-Uta C, Bremner A, Mauri M, Terra VS, Cuccui J, Wren BW, Vervelde L, Stevens MP; Glycoengineering of Veterinary Vaccines Consortium. (2021) Evaluation of a Campylobacter jejuni N-glycan-ExoA glycoconjugate vaccine to reduce C. jejuni colonisation in chickens. Vaccine, 39(51):7413-7420. doi: 10.1016/j.vaccine.2021.10.085.
• Russell KM, Smith J, Bremner A, Chintoan-Uta C, Vervelde L, Psifidi A, Stevens MP. Transcriptomic analysis of caecal tissue in inbred chicken lines that exhibit heritable differences in resistance to Campylobacter jejuni. BMC Genomics, 22(1):411. doi: 10.1186/s12864-021-07748-2.
• Nash TJ, Morris KM, Mabbott NA, Vervelde L. (2021) Inside-out chicken enteroids with leukocyte component as a model to study host-pathogen interactions. Communications Biology 4(1), 377. doi: 10.1038/s42003-021-01901-z.
• Bremner A, Kim S, Morris KM, Nolan MJ, Borowska D, Wu Z, Tomley F, Blake DP, Hawken R, Kaiser P and Vervelde L. (2021) Kinetics of the Cellular and Transcriptomic Response to Eimeria maxima in Relatively Resistant and Susceptible Chicken Lines. Frontiers in Immunology, 12, 882, doi.org/10.3389/fimmu.2021.653085
• Sutton K M, Morris K M, Borowska D, Sang H, Kaiser P, Balic A, Vervelde L. (2021) Characterization of Conventional Dendritic Cells and Macrophages in the Spleen Using the CSF1R-Reporter Transgenic Chickens. Frontiers in Immunology, 12,528 doi:10.3389/fimmu.2021.636436
• Alber A, Stevens MP, Vervelde L. (2021) The bird's immune response to avian pathogenic Escherichia coli. Avian Pathology. 1-10, doi: 10.1080/03079457.2021.1873246.
• P. Vohra, C. Chintoan-Uta, V.S. Terra, A. Bremner, J. Cuccui, B.W. Wren, L. Vervelde, M.P. Stevens. (2020) Evaluation of Glycosylated FlpA and SodB as subunit vaccines against Campylobacter jejuni colonisation in chickens. Vaccines 8(3), 520. doi: 10.3390/vaccines8030520.
• A. Alber, K.M. Morris, K.J. Bryson, K.M. Sutton, M.S. Monson, C. Chintoan-Uta, D. Borowska S.J. Lamont, C. Schouler, P. Kaiser, M.P. Stevens, L. Vervelde. (2020) Avian Pathogenic Escherichia coli (APEC) Strain-dependent immunomodulation of respiratory granulocytes and mononuclear phagocytes in CSF1R-reporter transgenic chickens. Frontiers in Immunology 10:3055. doi: 10.3389/fimmu.2019.03055.
• S. Keep, S. Sives, P. Stevenson-Leggett, P. Britton, L. Vervelde*, E. Bickerton. (2020) Limited cross-protection against infectious bronchitis provided by recombinant infectious bronchitis viruses expressing heterologous spike glycoproteins. Vaccines 8, 330. doi:10.3390/vaccines8020330 *joined last author
• S. Keep, P. Stevenson-Leggett, A. Steyn, M.S. Oade, I. Webb, J. Stuart, L. Vervelde, P. Britton, H.J. Maier, E. Bickerton. (2020) Temperature sensitivity: a potential method for the generation of vaccines against the avian coronavirus Infectious Bronchitis Virus. Viruses 2020, 12, 754; doi:10.3390/v12070754
• C. Chintoan-Uta, T. Wisedchanwet, L. Glendinning, A. Bremner, A. Psifidi, L. Vervelde, K. Watson, M. Watson, M.P. Stevens. (2020) Role of caecal microbiota in the differential resistance of inbred chicken lines to colonization by Campylobacter jejuni. Applied Environmental Microbiology AEM.02607-19. doi: 10.1128/AEM.02607-19.
• K.J. Bryson, D. Garrido, M. Esposito, G. McLachlan, P. Digard, C. Schouler, R. Guabiraba, S. Trapp, L. Vervelde. (2020) Precision cut lung slices: a novel versatile tool to examine host-1 pathogen interaction in the chicken lung. Veterinary Research 51(1):2. doi: 10.1186/s13567-019-0733-0.
• A. Balic, C. Chintoan-Uta, P. Vohra, K.M. Sutton, R.L. Cassady-Cain, T. Hu, D.S. Donaldson, M.P. Stevens, N.A. Mabbott, D.A. Hume, H.M. Sang, L. Vervelde. (2019) Antigen sampling CSF1R-expressing epithelial cells are the functional equivalents of mammalian M Cells in the avian Follicle-Associated Epithelium. Frontiers in Immunology 22;10:2495. doi:10.3389/ fimmu.2019.02495.
• D. Borowska, R. Kuo, R.A. Bailey, K.A. Watson, P. Kaiser, L. Vervelde, M.P. Stevens. (2019) Highly multiplexed quantitative PCR-based platform for evaluation of chicken immune responses. PLoS One 14(12):e0225658. doi: 10.1371/journal.pone.0225658.
• N.B. Burkhardt, S. Röll, A. Staudt, D. Elleder, S. Härtle, T. Costa, A. Alber, M.P. Stevens, L. Vervelde, B. Schusser, B. Kaspers. (2019) The long Pentraxin PTX3 is of major importance among acute phase proteins in chickens. Frontiers in Immunology. 10:124. doi.org /10.3389/fimmu.2019.00124
• P. Chakraborty, R. Kuo, L. Vervelde, B.M. Dutia, P. Kaiser, J. Smith. (2019) Macrophages from susceptible and resistant chicken lines have different transcriptomes following Marek's Disease Virus Infection. Genes (Basel). 10, 74; doi:10.3390/genes10020074
• T. Hu, Z. Wu, S.J. Bush, L. Freem, L. Vervelde, K.M. Summers, D.A. Hume, A. Balic, P. Kaiser. (2019) Characterization of Subpopulations of Chicken Mononuclear Phagocytes That Express TIM4 and CSF1R. Journal of Immunology. 202, 1186-1199.
• A. Alber, T. Costa, C. Chintoan-Uta, K.J. Bryson, P. Kaiser, M.P. Stevens, L. Vervelde. (2019) Dose-dependent differential resistance of inbred chicken lines to avian pathogenic Escherichia coli challenge. Avian Pathology. 48, 157-167.
• S. Hussain, M.L. Turnbull, H.M. Wise, B.W. Jagger, P.M. Beard, K. Kovacikova, J.K. Taubenberger, L. Vervelde, O.G. Engelhardt, P. Digard. (2018) Mutation of influenza A virus PA-X decreases pathogenicity in chicken embryos and can increase the yield of reassortant candidate vaccine viruses. Journal of Virology. 93:e01551-18.
• K. Sutton, T. Costa, A. Alber, K. Bryson, D. Borowska, A. Balic, P. Kaiser, M. Stevens, L. Vervelde. (2018) Visualisation and characterisation of mononuclear phagocytes in the chicken respiratory tract using CSF1R-transgenic chickens. Veterinary Research, 49, 104.
• S. Ellis, S. Keep, P. Britton, S. de Wit, E. Bickerton, L. Vervelde. (2018). Recombinant Infectious Bronchitis Viruses expressing chimaeric spike glycoproteins induce partial protective immunity against homologous challenge despite limited replication in vivo. Journal of Virology, 92:e01473-18.
• D. Garrido, A. Alber, E. Kut, N.K. Chanteloup, A. Lion, A. Trotereau, J. Dupont, K. Tedin, B. Kaspers, L. Vervelde, S. Trapp, C. Schouler, R. Guabiraba. (2018) The role of type I interferons (IFNs) in the regulation of chicken macrophage inflammatory response to bacterial challenge. Developmental and Comparative Immunology, 86, 156-170.
• S. Kim, P. Kaiser, D. Borowska, and L. Vervelde. (2018) Synergistic effect of co-stimulation of membrane and endosomal TLRs on chicken innate immune responses. Veterinary Immunology Immunopathology, 199, 15-21.
• I. Pastor-Fernández, S. Kim, K. Billington, J. Bumstead, V. Marugán-Hernández, T. Küster, D.J.P. Ferguson, L. Vervelde, D.P. Blake, F.M. Tomley. (2018) Development of cross-protective Eimeria-vectored vaccines based on apical membrane antigens. International Journal of Parasitology, 48, 505-518.
• S. Kim, A. Vela, S.M. Clohisey, S. Athanasiadou, P. Kaiser, M.P. Stevens, L. Vervelde. (2018) Host-specific differences in the response of cultured macrophages to Campylobacter jejuni capsule and O-methyl phosphoramidate mutants. Veterinary Research, 49, 3.
• L. Glendinning G. McLachlan, L. Vervelde. (2017) Age-related differences in the respiratory microbiota of chickens. PLoS One, 12(11):e0188455.
• S.H. Andersen, L. Vervelde*, K. Sutton, L.R. Norup, E. Wattrang, H.R. Juul-Madsen, T.S. Dalgaard. Quantification and phenotypic characterisation of peripheral IFN-γ producing leucocytes in chickens vaccinated against Newcastle disease. Veterinary Immunology Immunopathology, 2017, 193-194:18-28. * joined first author
• P. Chakraborty, L. Vervelde, R.G. Dalziel, P.S. Wasson, V. Nair V, B.M. Dutia and P. Kaiser. (2017) Marek's disease virus infection of phagocytes: a de novo in vitro infection model. Journal of General Virology, 98(5), 1080-1088.
• C.A. Jansen, D.A. van Haarlem, B. Sperling, P.J. van Kooten, E. de Vries, B.C. Viertlboeck, L. Vervelde, T.W. Göbel. (2016) Identification of an Activating Chicken Ig-like Receptor Recognizing Avian Influenza Viruses. Journal of Immunology, 197, 4696-4703.
• T.J. Hagenaars, E.A.J. Fischer, C.A. Jansen, J.M.J. Rebel, D. Spekreijse, L. Vervelde, J.A. Backer, M.C.M. de Jong, A.P. Koets. (2016) Modelling the Innate Immune Response against Avian Influenza Virus in Chicken. PLoS ONE 11(6): e0157816.doi:10.1371/ journal.pone. 0157816
• Z. Wu, T. Hu, L. Rothwell, L. Vervelde, P. Kaiser, K. Boulton, M.J. Nolan, F.M. Tomley, D.P. Blake, D.A. Hume. (2016) Analysis of the function of IL-10 in chickens using specific neutralising antibodies and a sensitive capture ELISA. Developmental and Comparative Immunology, 63, 206-212.
• T. Hu, Z. Wu, L. Vervelde, L. Rothwell, D.A. Hume, P. Kaiser. (2016) Functional annotation of the T-cell immunoglobulin mucin family in birds. Immunology, 148, 287-303.
• C. Garcia-Morales, S. Nandi, D. Zhao, K. Sauter, L. Vervelde, D. McBride, H. Sang, M. Clinton, D. Hume. (2015) Cell-autonomous sex differences in gene expression in chicken bone marrow-derived macrophages. Journal of Immunology, 194, 2338-2344.
• V. Garceau, A. Balic, C. Garcia-Morales, K. Sauter, M. McGrew, J. Smith, L. Vervelde, A. Sherman, T. Fuller, T. Oliphant, J. Shelley, R. Tiwari, T. Wilson, C. Chintoan-Uta, D. Burt, M. Stevens, H. Sang, D. Hume. (2015) The development and maintenance of the mononuclear phagocyte system of the chick is controlled by signals from the macrophage colony-stimulating factor (CSF1) receptor. BMC Biology, 13(1):12. doi: 10.1186/s12915-015-0121-9.
• K.M. Sutton, T. Hu, Z. Wu, B. Siklodi, L. Vervelde, P. Kaiser. (2015) The functions of the avian receptor activator of NF-κB ligand (RANKL) and its receptors, RANK and osteoprotegerin, are evolutionarily conserved. Developmental and Comparative Immunology, 51, 170-184.
• E.D. de Geus, W.G. Degen, D.A. van Haarlem, C. Schrier, F. Broere, L. Vervelde. (2015) Distribution patterns of mucosally applied particles and characterization of the antigen presenting cells. Avian Pathology, 44(3), 222-229.
• G.S. Freidl , E. de Bruin, J. van Beek, J. Reimerink, S. de Wit, G. Koch, L. Vervelde, H.J. van den Ham, M.P. Koopmans. (2014) Getting More Out of Less - A Quantitative Serological Screening Tool for Simultaneous Detection of Multiple Influenza A Hemagglutinin-Types in Chickens. PLoS One, 9(9): e108043.
• S. Kuchipudi, M. Tellabati, S. Sebastian, B. Londt, C. Jansen, L. Vervelde, S. Brookes, I. Brown, S. Dunham and K. Chang. (2014) Highly pathogenic avian influenza virus infection in chickens but not ducks is associated with elevated host immune and pro-inflammatory responses. Veterinary Research, 45, 118-136.
• A. Balic, C. Garcia-Morales, L. Vervelde, H. Gilhooley, A. Sherman, V. Garceau, P. Kaiser, D.A. Hume, H.M. Sang. (2014) Visualisation of the avian mononuclear phagocyte system using novel transgenic reporter genes based upon conserved control elements of the CSF1R locus. Development, 141, 3255-3265.
• K. Chrząstek, D. Borowska, P. Kaiser, L. Vervelde. (2014) Class B CpG ODN stimulation upregulates expression of TLR21 and IFN-γ in chicken Harderian gland cells. Veterinary Immunology and Immunopathology, 160, 293-299.
• J. Post, B. Peeters, J.B. Cornelissen, L. Vervelde, J.M. Rebel. (2013) Contribution of the NS1 Gene of H7 Avian Influenza Virus Strains to Pathogenicity in Chickens. Viral Immunology, 26, 396-403. All manuscripts together with Rebel originate in a collaborative grant and depending on the contribution authorships vary (first, last and co-author).
• C.A. Jansen, E.D. Geus, D.A. van Haarlem, P.M. van de Haar, B.Z. Löndt, S.P. Graham, T.W. Göbel, W. van Eden, S.M. Brookes, L. Vervelde. (2013) Differential lung NK cell responses in avian influenza virus infected chickens correlate with pathogenicity. Scientific Reports, 3, 2478
• W.J.C. Swinkels, J. Hoeboer, R. Sikkema, L. Vervelde, A.P. Koets. (2013) Vaccination induced antibodies to recombinant avian Influenza A virus M2 protein or synthetic M2e peptide do not bind to the M2 protein on the virus or virus infected cells. Virology Journal, 10, 206-213.
• E.D. de Geus, B. Tefsen, D.A. van Haarlem, W. van Eden, I. van Die, L. Vervelde. (2013) Glycans from avian influenza virus are recognized by chicken dendritic cells and are targets for the humoral immune response in chicken. Molecular Immunology, 56, 452-462.
• C. Keijzer, R. Spieringa, A.L. Silva, W. van Eden, W. Jiskoot, L. Vervelde, F. Broere. (2013) PLGA nanoparticles enhance the expression of retinaldehyde dehydrogenase enzymes in dendritic cells and induce FoxP3+ T-cells in vitro. Journal of Controlled Release, 168, 35-40.
• J. Post, E.D. de Geus, L. Vervelde, J.B. Cornelissen, J.M. Rebel. (2013) Systemic distribution of different low pathogenic avian influenza (LPAI) viruses in chicken. Virology Journal, 10, 23-30.
• J. Cornelissen, L. Vervelde, J. Post, J. Rebel. (2013) Differences in highly pathogenic avian influenza viral pathogenesis and associated early inflammatory response in chickens and ducks. Avian Pathology, 42, 347-364.
• L. Vervelde, M.G.R. Matthijs, D.A. van Haarlem, J.J. de Wit, C.A. Jansen. (2013) Rapid NK-cell activation in chicken after infection with Infectious Bronchitis Virus M41. Veterinary Immunology and Immunopathology, 151, 337-341.
• E.D. de Geus and L. Vervelde. (2013) Regulation of macrophage and dendritic cell function by pathogens and through immunomodulation in the avian mucosa. Developmental and Comparative Immunology, 41, 341-351.
• L. Vervelde, S. Reemers, D.A. van Haarlem, J. Post, E. Claassen, J.M.J. Rebel, C.A. Jansen. (2013) Chicken dendritic cells are susceptible to highly pathogenic avian influenza viruses which induce strong cytokine responses. Developmental and Comparative Immunology, 39, 198-206.
• S.A. Burt, M.H.G. Tersteeg-Zijderveld, B.G.M. Jongerius-Gortemaker, L. Vervelde, J.C.M. Vernooij. (2013) In vitro inhibition of Eimeria tenella invasion of epithelial cells by phytochemicals. Veterinary Parasitology, 191, 374-378.
• E.D. de Geus, J.M. Rebel and L. Vervelde. (2012) Induction of respiratory immune responses in the chicken; implications for development of mucosal avian influenza virus vaccines. Veterinary Quarterly, 32, 75-86.
• J.B.W.J. Cornelissen, J. Post, B. Peeters, L. Vervelde, J.M.J. Rebel. (2012) Differential innate responses of chickens and ducks to low pathogenic avian influenza. Avian Pathology, 41, 519-529.
• E.D. de Geus, C.A. Jansen, L. Vervelde. (2012) Uptake of particulate antigens in a non-mammalian lung; phenotypic and functional characterization of avian respiratory phagocytes using bacterial or viral antigens. Journal of Immunology, 188, 4516-4526.
• E.D. de Geus, J.M. Rebel, L. Vervelde. (2012) Kinetics of the avian influenza-specific humoral responses in lung are indicative of local antibody production. Developmental and Comparative Immunology, 36, 317-322.
• S.S.N. Reemers, D.A. van Haarlem, A.J.A.M. Sijts, L. Vervelde, C.A. Jansen. (2012) Identification of novel avian influenza virus derived CD8+ T-cell epitopes. PLoS ONE, 7(2): e31953. doi:10.1371/journal.pone.0031953. I gave last authorship to my post doc to express gratitude for her contribution to the group and to encourage her to become an independent fellow.
• E.D. de Geus, D.A. van Haarlem, O.N. Poetri, J.J. de Wit , L. Vervelde. (2011) A lack of antibody formation against inactivated influenza virus after aerosol vaccination in presence or absence of adjuvantia. Veterinary Immunology and Immunopathology, 143, 143-147.
• J.M.J. Rebel, B. Peeters, H. Fijten, J. Post, J. Cornelissen, L. Vervelde. (2011) Highly pathogenic or low pathogenic avian influenza virus subtype H7N1 infection in chicken lungs: small differences in general acute responses. Veterinary Research, 42, 10-20.
• S.S. Reemers, C.A. Jansen, M.J. Groot Koerkamp, D.A. van Haarlem, P.H. van de Haar, W. Degen, W. van Eden, L. Vervelde. (2010) Reduced immune reaction prevents immunopathology after challenge with avian influenza virus: a transcriptomics analysis of adjuvanted vaccines. Vaccine, 28, 6351-6360.
• S.S. Reemers, D. van Leenen, M.J. Koerkamp, D.A. van Haarlem, P.H. van de Haar, W. van Eden, L. Vervelde. (2010) Early host responses to avian influenza A virus are prolonged and enhanced at transcriptional level depending on maturation of the immune system. Molecular Immunology, 47, 1675-1685.
• C.A. Jansen, P.M. van de Haar, D.A. van Haarlem, P. van Kooten, S.J. de Wit, W. van Eden, B.C. Viertlböck, T.W. Göbel, L. Vervelde. (2010) Identification of new populations of chicken natural killer (NK) cells. Developmental and Comparative Immunology, 34, 759-767.
• S. Reemers, E. Veldhuizen, C. Fleming, D. van Haarlem, H. Haagsman, L. Vervelde. (2010) Transcriptional expression levels of chicken collectins are affected by avian influenza A virus inoculation. Veterinary Microbiology, 141, 379-384.
• C.M.W. van Stijn, M. van den Broek, L. Vervelde, R. A. Alvarez, R. D. Cummings, B. Tefsen, I. van Die. (2010) Vaccination-induced IgG response to Gal α1-3GalNAc glycan epitopes in lambs protected to Haemonchus contortus challenge infection. International Journal of Parasitology, 40, 215-222.
• S. Reemers, D. van Haarlem, M. Groot Koerkamp, L. Vervelde. (2009) Differential gene expression and host response profiles against influenza virus within the chicken lung due to anatomy and airflow. Journal of General Virology, 90, 2134-2146.
• D.A. van Haarlem, P.J.S. van Kooten, L. Rothwell, P. Kaiser, L. Vervelde. (2009) Characterisation and expression analysis of the chicken interleukin-7 receptor alpha chain. Developmental and Comparative Immunology, 33, 1018-1026.
• S.S. Reemers, M.J. Groot Koerkamp, F. C. Holstege, W. van Eden, L. Vervelde. (2009) Cellular host transcriptional responses to Influenza A virus in chicken tracheal organ cultures differ from responses in in vivo infected trachea. Veterinary Immunology and Immunopathology, 132, 91-100.
• F.A. Looringh van Beeck, P. Reinink, R. Hermsen, D.M. Zajonc, M.J. Laven, A. Fun, M. Troskie, N.J. Schoemaker, D. Morar, J.A. Lenstra, L. Vervelde, V.P.M.G.
• Rutten, W. van Eden, I. Van Rhijn. (2009) Functional CD1d and/or NKT cell invariant chain transcript in horse, pig, African elephant, and guinea pig, but not in ruminants. Molecular Immunology, 46, 1424-1431.
• M.P. Ariaans, P.M. van de Haar, E.J. Hensen, L. Vervelde. (2009) Infectious Bronchitis Virus induces acute interferon-gamma production through polyclonal stimulation of chicken leukocytes. Virology, 385, 68-73.
• R.M. Dwars, M.G.R. Matthijs, A.J.J.M. Daemen, L. Vervelde, W.J.M. Landman. (2009) Progression of lesions in the respiratory tract of broilers after single infection with Escherichia coli compared to superinfection with Escherichia coli after infection with infectious bronchitis virus. Veterinary Immunology and Immunopathology, 127, 65-76.
• M.G.R. Matthijs, M.P. Ariaans, R.M. Dwars, J.H.H. van Eck, A. Bouma, A. Stegeman, L. Vervelde. (2009) Course of infection and immune responses in the respiratory tract of IBV infected broilers after superinfection with E. coli. Veterinary Immunology and Immunopathology,127, 77-84
• M.P. Ariaans, M.G.R. Matthijs, D. van Haarlem, P. van de Haar, J.H.H. van Eck, E.J. Hensen, L. Vervelde. (2008) The role of phagocytic cells in enhanced susceptibility of broilers to colibacillosis after Infectious Bronchitis Virus infection. Veterinary Immunology and Immunopathology, 123, 240-250.M.P. Ariaans,
• P.M. van de Haar, J.W. Lowenthal, W. van Eden, E.J. Hensen, L. Vervelde. (2008) ELISPOT and intracellular cytokine staining: novel assays for quantifying T cell responses in the chicken. Developmental and Comparative Immunology, 32, 1398-1404.A. Hogenkamp, N. Isohadouten, S.S.N. Reemers, R.A.P. Romijn,
• W. Hemrika, M.R. White, B. Tefsen, L. Vervelde, M. van Eijk, E.J.A. Veldhuizen, H. P. Haagsman. (2008) Chicken Lung Lectin is a functional C-type lectin and inhibits haemagglutination by Influenza A Virus. Veterinary Microbiology, 130, 37-46.
• N. Bakker, L. Vervelde, K. Kanobana, D.P. Knox, A.W.C.A. Cornelissen, E. de Vries, A.P. Yatsuda. (2004) Vaccination against the nematode Haemonchus contortus with a thiol-binding fraction from the excretory/secretory products (ES). Vaccine, 22, 618-628.
• K. Kanobana, H.W. Ploeger, M. Eysker, L. Vervelde. (2004) Individual variation and effect of priming dose level on establishment, growth and fecundity of Cooperia oncophora in re-infected calves. Parasitology, 128, 99-109.
• L. Vervelde, N. Bakker, F.N.J. Kooyman, A.W.C.A. Cornelissen, C.M.C. Bank, A.K. Nyame, R.D. Cummings, I. van Die. (2003) Vaccination-induced protection of lambs against the parasitic nematode Haemonchus contortus correlates with high IgG antibody responses to the LDNF glycan antigen. Glycobiology, 13, 795-804.
• K. Kanobana, A. Koets, N. Bakker, H.W. Ploeger, L. Vervelde. (2003) T-cell mediated immune responses in calves primary infected or re-infected with Cooperia oncophora: similar effector cells but different timing. International Journal for Parasitology, 33, 1503-1514.
• K. Kanobana, A. Koets, F.N.J. Kooyman, N. Bakker, H.W. Ploeger, L. Vervelde. (2003) B cells and antibody responses in calves primary infected or re-infected with Cooperia oncophora: influence of priming dose and host responder types. International Journal of Parasitology, 33, 1487-1502.
• L. Vervelde, M.A.W. van Leeuwen, M. Kuidenier, F.N.J. Kooyman J.F. Huntley, I. van Die, A.W.C.A. Cornelissen. (2002) Protection studies with recombinant excretory/secretory proteins of Haemochus contortus. Parasite Immunology, 24,189-201.
• K. Kanobana, H.W. Ploeger, L. Vervelde. (2002) Immune expulsion of the trichostrongylid Cooperia oncophora is associated with increased eosinophilia and mucosal IgA. International Journal of Parasitology, 32,1389-1398.
• M. Gauly, M. Kraus, L. Vervelde, M.A.W. van Leeuwen, G. Erhardt. (2002) Estimating genetic differences in natural resistance in Rhön and Merinoland sheep following experimental Haemonchus contortus infection. Veterinary Parasitology, 106, 55-67.
• K. Kanobana, L. Vervelde, M. van der Veer, M. Eysker, H.W. Ploeger. (2001) Characterisation of host responder types after a single Cooperia onchophera infection: kinetics of the systemic immune response. Parasite Immunology, 23, 641-653.
• L. Vervelde, F.N. Kooyman, M.A.W. van Leeuwen, H.D.F.H. Schallig, A. MacKellar, J.F. Huntley, A.W.C.A. Cornelissen. (2001) Age-related protective immunity after vaccination with Haemonchus contortus excretory/secretory proteins. Parasite Immunology, 23, 419-426.
• J.F. Huntley, J. Redmond, W. Welfare, G. Brennan, F. Jackson, F. Kooyman, L. Vervelde. (2001) Studies on the immunoglobulin E responses to Teladorsagia circumcincta in sheep: purification of a major high molecular weight allergen. Parasite Immunology, 23, 227-235.
• S.H.M. Jeurissen, E. Claassen, A.G. Boonstra-Blom, L. Vervelde, E. M. Janse. (2000) Immunocytochemical techniques to investigate the pathogenesis of infectious micro-organisms and the concurrent immune response of the host. Developmental and Comparative Immunology, 24, 141-151.
• I. van Die, V. Gomord, F.N. Kooyman, T.K. van den Berg, R.D Cummings, L. Vervelde. (1999) Core alpha 1→3 fucose is a common modification of N-glycans in parasitic helminths and constitutes an important epitope for IgE from Haemonchus contortus infected sheep. FEBS Letters, 463, 189-193.
• L. Vervelde, E.M. Janse, A.N. Vermeulen, S.H.M. Jeurissen. (1998) Induction of a local and systemic immune response using cholera toxin as vehicle to deliver antigen in the lamina propria of the chicken intestine. Veterinary Immunology and Immunopathology, 62, 261-272.
• L. Vervelde and T.F. Davison. (1997) Comparison of the in situ changes in lymphoid cells during infection with infectious bursal disease virus in chickens of different ages. Avian Pathology, 26, 803-821.
• C.J. Rothwell, L. Vervelde, T.F. Davison. (1996) Identification of chicken Bu-1 alloantigens using the monoclonal antibody AV20. Veterinary Immunology and Immunopathology, 55, 225-234.
• L. Vervelde, A.N. Vermeulen, S.H.M. Jeurissen. (1996) In situ changes in leucocyte subpopulations after infection with Eimeria tenella in chickens. Parasitology, 18, 247-256.
• S.H.M. Jeurissen, E.M. Janse, A.N. Vermeulen, L. Vervelde. (1996) Eimeria tenella infections in chickens: aspects of host-parasite interaction. Veterinary Immunology and Immunopathology, 54, 231-238.
• L. Vervelde, A.N. Vermeulen, S.H.M. Jeurissen. (1995) Eimeria tenella: sporozoites rarely enter leucocytes in the caecal epithelium of the chicken (Gallus domesticus). Experimental Parasitology, 81, 29-38.
• S.H.M. Jeurissen, L. Vervelde and E. Marga Janse. (1994) Structure and function of lymphoid tissues of the chicken. Poultry Science Reviews, 5, 183-207.
• L. Vervelde, A.N. Vermeulen, S.H.M. Jeurisssen. (1993) Common molecules on Eimeria tenella sporozoites and cecal epithelium of chickens. Infection and Immunity, 61, 4504-4506.
• L. Vervelde and S.H.M. Jeurissen. (1993) Postnatal development of intra-epithelial leucocytes in the chicken digestive tract: phenotypical characterization in situ. Cell and Tissue Research, 274, 295-301.
• L. Vervelde, A.N. Vermeulen, S.H.M. Jeurisssen. (1992) In situ immunocytochemi¬cal detection of cells containing antibodies specific for Eimeria tenella antigens. Journal of Immunological Methods, 151, 191-199.

Editor

• Avian Immunology 3rd Edition (2021) Eds. B. Kaspers, K.A. Schat, T. Göbel, L. Vervelde. Elsevier.

Book chapters

• N. Nagy, I. Olah and L. Vervelde. (2024) Structure of the avian lymphoid system. In: Avian Immunology, 3rd edition. Eds. B. Kaspers, K.A. Schat, T.W. Göbel and L. Vervelde. Elsevier Ltd., London, U.K.
• K. Sutton, A. Balič, B. Kaspers and L. Vervelde. (2024) Macrophages and dendritic cells. In: Avian Immunology, 3rd edition. Eds. B. Kaspers, K.A. Schat, T.W. Göbel and L. Vervelde. Elsevier Ltd., London, U.K.
• S. Härtle, L. Vervelde and B. Kaspers. (2024) The avian respiratory immune system. In: Avian Immunology, 3rd edition. Eds. B. Kaspers, K.A. Schat, T.W. Göbel and L. Vervelde. Elsevier Ltd., London, U.K.
• L. Vervelde and J. Kaufman. (2019) Avian immune responses to virus infection. In: Avian Virology: Current Research and Future Trends. Ed. S.K. Samal. Caister Academic Press, U.K.
• L. Vervelde and D.R. Kapczynski. (2016) The innate and adaptive response to avian influenza virus. In: Animal Influenza, 2nd Edition, chpt 6, pp135-152. Ed. D. Swayne. Wiley Blackwell.
• I. Olah, N. Nagy and L. Vervelde. (2013) Structure of the avian lymphoid system. In: Avian Immunology, 2nd edition. Eds. K.A. Schat, B. Kaspers and P. Kaiser. Elsevier Ltd., London, San Diego C.A
• I. Olah and L. Vervelde. (2008) Structure of the avian lymphoid system. In: Avian Immunology, 1st edition, Eds. F. Davison, B. Kaspers, and K.A. Schat. Elsevier Ltd., London, San Diego C.A.